PTMVision: Interactive Visualization of Post Translational Modifications
Understanding the intricate landscape of PTMs is crucial for unraveling the complex mechanisms underlying cellular processes and diseases. With PTMVision, researchers can effortlessly analyze and explore PTM data derived from various sources, including search engines such as ionbot, MSFragger, Sage, or from a plain CSV table format processed from mass spectrometry (MS) data.
-
Usage Instruction
- Upload Data
- • Upload your data or re-upload existing session data at panel ; Enter the required input and click on Submit. Alternatively, you can load an example session. Your current session data can be downloaded by clicking on in the header menu on the right.
- Overview Proteins
-
• After data transfer and successful
processing, you will receive an overview of all PTMs in your
data in panel .
• A tabular overview of all proteins available from your data is given in panel . The table can be filtered for protein name, UniProt identifier and modification names. Select a single protein from the table and click Display to get a detailed view of the PTMs in the selected protein. - Explore Detail
-
Detail information about the occurrence of PTMs for the selected
protein is displayed in panel
. You can switch
between two display modes via the top-right button on the panel:
• The Modification View focuses on the occurrence of PTMs along the selected protein primary sequence as well as per amino acid.
• The Structure View focuses on the occurrence of PTMs in the context of residues that are in close spatial contact. -
Disclaimer
-
• We recommend using PTMVision in Chrome or
Firefox for optimal performance. Safari has issues when
visualising larger datasets.
• Note that PTMVision serves solely to visualize the content provided in the input and does not conduct any further quality control. The localization of modifications still remains a challenging task and may yield imprecise results.
• PTMVision will be continuously updated and improved, including the addition of filters for localisation scores as soon as they will be reported by search engines.
Upload post-translational modification data from open or closed search or Restart previous PTMVision session
.zlib file: